Nahorski et al. (2012) and Medvetz et al. (2012) identified an interaction between FLCN and Plakophilin-4 and reported opposing effects of FLCN loss on RhoA signalling in vitro. Nahorski et al. (2012) observed that cells deficient in FLCN have increased RhoA expression and activity. These FLCN deficient cells also displayed faster cell migration, which was reversed when RhoA signalling was blocked using a ROCK inhibitor. However, Medvetz et al. (2012) report that RhoA signalling is inhibited in FLCN-null cells, and that these cells display a slow cell migration phenotype compared to wild-type cells. Additionally, the authors used a conditional mouse FLCN allele to delete FLCN in the epidermis. These mice showed a hyper-proliferative epidermal phenotype, similar to that of other Rho signalling gene knock out mice.