Updated January, 2017

Country	Number of families	References
USA	227	Aivaz et al., 2015; Zamora et al., 2015; Prichett et al., 2015; Mikesell et al., 2014; Pritchard et al., 2014; Auerback et al., 2014; Kolb et al., 2014; Toro et al. 2007; Unpublished*
Japan	120	Tanegashima et al., 2016; Yukawa et al., 2016; Furuya et al., 2016; Ding et al., 2015; Kamada et al., 2015; Ebana et al. 2015; Nishida et al., 2015; Okada et al., 2015; Miura et al., 2015; Yamada et al., 2014; Matsuoka et al., 2014; Sakaguchi et al., 2014; Kuroda et al., 2014; Murakami et al., 2014; Onuki et al., 2014; Kumasaka et al., 2014; Kunogi Okura et al., 2013; Nakamura et al., 2013; Tobino and Seyama, 2012; Furuya et al., 2012; Kashiwada et al. 2012; Tobino et al. 2011; Hayashi et al. 2010; Kunogi et al. 2010; Koga et al. 2009; Ishii et al. 2009; Imada et al. 2009; Misago et al., 2008; Gunji et al. 2007; Kawasaki et al. 2005; Takahashi et al. 2001
France	72	Benusiglio et al., 2014b; Ardilouze et al., 2014; Zenone, 2013; Spring et al., 2013; van Denhove et al., 2011; Vinit et al. 2010; Steff et al., 2010; Kluger et al. 2010; Le Guyadec et al. 1998; Unpublished*
The Netherlands	60	Johannesma et al., 2014d; Gijezen et al., 2014;  Johannesma et al., 2014b; Johannesma et al., 2014a; Menko et al., 2013; Houweling et al., 2011; Unpublished*
UK	38	Felton and Madan, 2012; Byrne et al., 2012; Hopkins et al. 2011; Warwick et al. 2010; Stavrakoglou et al. 2010; Jarrett et al. 2009; Sundaram et al. 2009; Woodward et al. 2008; Unpublished*
Denmark	31	Rossing et al., 2016
China	26	Li et al., 2017; Dong et al., 2016; Ding et al., 2015; Lin et al.,  2014; Liu et al., 2014; So et al. 2009; Ren et al. 2008
Italy	16	Castellucci et al., 2016; Tamburrini et al. 2015; Nachira et al., 2014; Attinà et al., 2013; Maffé et al. 2011; Palmirotta et al. 2008; Scalvenzi et al. 1998
Germany	12	Sander et al., 2013; Brehmer et al., 2013; Lichte et al., 2012; Michels et al. 2012; Sattler et al., 2012; Westermann et al. 2010; Janitzky et al. 2008; Lamberti et al. 2005; Gambichler et al. 2000; Walter et al. 1997
Korea	8	Seo et al., 2014; Kim et al., 2012; Shin et al., 2011; Park et al., 2011; Bae et al., 2011; Kim et al. 2008
Spain	8	Martínez-Pérez et al., 2016; Gorospe et al., 2015; Mota-Burgos et al., 2013; Alonso-Gonzalez et al., 2011; Sempau et al., 2010; Truchuelo et al. 2011; Fuertes et al. 2009; De La Torre et al. 1999
Sweden	7	Bradley et al., 2014; Khoo et al. 2001
Turkey	6	Demir et al,. .2016; Bakan et al., 2015; Kilincer et al.,  2014; Tefekli et al., 2012;
Switzerland	5	Näf et al. 2015; De Keyzer et al., 2014; Fröhlich et al. 2008; Pittet et al. 2006
Australia	4	Ge and Lowe, 2016; Bondavalli et al.,  2015; Cocciolone et al., 2010; Godbolt et al. 2003
Taiwan	4	Furuya et al., 2016; Yang et al., 2013; Yang and Chiang, 2013; Furuya et al., 2012
Canada	3	Pierce et al., 2011; Souza et al. 2005; Birt et al. 1977
Portugal	3	Cesar et al., 2016; Martins et al., 2016; Lencastre et al., 2013;
Brazil	2	Escuissato et al., 2014; Pimenta et al., 2012
Ireland	2	Menzies et al., 2016; Lynch et al., 2011
Belgium	1	Schreuer et al., 2011
Egypt	1	Fahmy et al. 2007
Finland	1	Painter et al. 2005
India	1	Ray et al., 2015
Iran	1	Jandaghi et al., 2013
Russia	1	Unpublished*
Somalia	1	Pritchett et al., 2014
Poland	1	Radzikowska et al. 2016
Indonesia	1	Wiyono et al., 2016
Total	663

Legend: This is a conservative estimate of the number of BHD families, arranged by country. References were only included where it could be determined that the patients in the cohort were unique and not reported elsewhere in the literature. Thus, the actual number of BHD families is likely to be higher.* – data from BHD Symposia.