BHD Cell Lines

 

Cell Line Species Description Reference/Source
UOK 257 Human FLCN-null epithelial cell line derived from a human male BHD renal cell carcinoma (RCC). Baba et al., 2006Yang et al., 2008 (National Cancer Institute, Bethesda, USA)
UOK 257-2 Human UOK 257-cell line with FLCN restored via the ViraPower Lentiviral Expression System (Invitrogen). Baba et al., 2006 (National Cancer Institute, Bethesda, USA)
NR22, NR24, NR32, NR45, NR49, NR54, NR64 Rat FLCN-null round/polygonal cells derived from a RCC in a 10-month old male Nihon rat. Matsumoto et al., 2009 (Juntendo University, Tokyo & Dainippon Sumitomo Pharma Company Ltd., Osaka, Japan)
ES cell Mouse Homozygous FLCN-null embryonic stem (ES) cells selected in Geneticin (G418). Cash et al., 2011 (University of Pennsylvania, Philadelphia, USA)
ES cell Mouse A variety FLCN-specific ES cell clones available, including gene traps and conditional knockouts. Mutant Mouse Regional Resource Centre

German Genetrap Consortium

TIGEM-IRBM Gene Trap Project

International Knockout Mouse Consortium

Further reading: all literature relating to this information, plus more, can be found in the BHD Literature Database.