As has been noted in our blog review of 2012, a great deal of research in the BHD field has been published in the past year. Thus, it is only appropriate to reflect these changes in an updated version of our interactive signalling diagram.
The FLCN-associated signalling diagram retains many of the features from previous versions, such as the clickable links which give further information about the various factors and signalling pathways, as well as clickable references which take you to the relevant PubMed entry or directly to the article for those that are open access. In addition, these references can be found in our regularly updated BHD Literature Database, and those that are freely available are also found in our BHD Article Library.
One major difference with the figure is that it highlights the factors and pathways that appear to be directly linked to FLCN, while related pathways which provide context for these associations are faded. Furthermore, there are now two pop-up boxes that can be opened and repositioned independently. The first shows the C-terminal structure of FLCN which was determined by Nookala et al. (2012) (as previously described here). It also illustrates the FLCN-associated interactome, which outlines the potential interacting partners of FLCN and their downstream effects. The second pop-up box notes the post-translational modifications that have been detected in FLCN and its interactors, such as phosphorylation and ubiquitination (which have been discussed in the blog here and here respectively).
An update of the “What is BHD?” text in the For Researchers section is coming soon too. In the meantime, if you have any comments or suggestions regarding the diagram or any other aspect of the website, please do not hesitate to email us at contact@BHDSyndrome.org or fill in our feedback form.
- Nookala RK, Langemeyer L, Pacitto A, Ochoa-Montaño B, Donaldson JC, Blaszczyk BK, Chirgadze DY, Barr FA, Bazan JF, & Blundell TL (2012). Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer. Open biology, 2 (8) PMID: 22977732