The BHD Literature Database has been updated with one paper.
Reiman et al. sought to identify novel pathways involving FLCN by analysing gene expression in isogenic FLCN-positive and FLCN-negative cells. They found 708 genes to be differentially expressed in the two cells lines, including cadherin and Wnt signalling genes. Comparison with a previously published gene expression dataset identified the RAB27B GTPase as a potential FLCN interactor. Kinexus protein array and Western blot analysis found five proteins to be putative targets of FLCN, including the apoptosis gene, CASP1. Further analysis of apoptosis genes found SMAC/DIablo and HtrA2 to also be potential FLCN targets.
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