Hsp90 is required for the folding, stability and activity of several drivers of oncogenesis. In a new study by Woodford et al. (2016) the authors show that Folliculin-interacting proteins (FNIP) 1 and 2, whose expression correlates with the cellular response to Hsp90 inhibitors, are co-chaperones of Hsp90 that function by inhibiting its ATPase activity.

This study is freely available to download in the BHD Article Library: Basic Research.