Review of stretch theory in BHD lung cyst pathology

A new review from Kennedy, Khabibullin & Henske (2016) summarises what is currently known about the pathogenesis of BHD pulmonary cysts in support of the stretch hypothesis. A reduction in FLCN results in increased cell-cell adhesion and the stretch hypothesis suggests that in areas of the lung which experience greater stress this can cause cyst formation. The areas of the lung most prone to this stress are where the majority of BHD cysts are located, although more research is required to understand the underlying pathology completely. The review ends with a summary of the remaining questions and future research directions.

Leave a Reply