The signalling diagram has been updated to include the following recent research papers:

• FNIP2 causes MNU-induced apoptosis (Sano et al., 2013)
• FLCN inhibits MMP9 (Pimenta et al., 2012)
• FLCN inhibits HIF-1a, mTORC1 and mTORC2 (Nishii et al., 2013)
• FLCN and PTEN compound heterozygosity causes oncogenesis (Pradella et al., 2013)
• FLCN and SSH2 are synthetically lethal (Lu et al., 2013)
• FLCN inhibits Cyclin D1 (Kawai et al., 2013)
• FLCN inhibits HIF1a (Gharbi et al., 2013)