BHD Literature Database Updated

The BHD Literature Database has been updated with a pathological study of BHD-associated pulmonary cysts in 11 individuals from 9 families.

The researchers found that the inner walls of BHD-associated cysts are lined with epithelial cells, and that many of the cysts exhibited internal septa or alveoli within an alveolus. Additionally, positive staining for phospho-S6 ribosomal protein expression pointed to activation of the mTOR pathway. The authors concluded by suggesting that BHD-associated cysts may be considered hamartoma-like cystic alveolar formations associated with disregulated mTOR signalling.

To find out more, download the latest version of the database here.

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